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What exactly is CBD? How does CBD oil work?

HWhen You hear the term "CBD" you will probably ask yourself two simple questions first: What is CBD? What does CBD help with?

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Well, CBD (cannabidiol) belongs to a group of compounds called cannabinoids, which are naturally found in both hemp and cannabis. Unlike THC, CBD does not have narcotic effects - on the contrary, it has sedative, anti-anxiety, and antipsychotic effects. CBD, along with THC, is one of the most studied compounds from the cannabinoid group.

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CBD chemical formula

In recent years, scientists have made great strides in studying the complex effects of CBD on the body. Below is a brief list outlining the effects of CBD:

  • sedative and antidepressant
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  • analgesic
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  • anti-inflammatory
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  • antioxidant
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  • antiepileptic
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We now know that CBD interacts with many receptors, proteins, and other chemicals in the brain. Through these interactions, there are changes in the activity of neurotransmitters, hormones, and in the operation of the body at the cellular level.
Through these interactions, CBD has been shown to affect many of the functions of the human body, ranging from circadian rhythm (sleep) and mental state, to the regulation of inflammation, pain and epileptic seizures. The answer to the question "What does CBD oil help with?" posed earlier is, as you can see, quite extensive.

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The human body itself produces cannabinoids as part of the so-called endocannabinoid system.
These include anandamide and 2-AG. The endocannabinoid system is responsible for regulating many physiological processes in our bodies, including mood, pain perception, appetite and cognitive function. CBD affects our endocannabinoid system in part by binding to its receptors.

According to a number of studies, CBD can affect neurogenesis, the process of creating new nerve cells in the brain. Currently, its antioxidant and anti-inflammatory effects are already widely known. All of this makes CBD a compound that offers great promise in the treatment of many conditions such as neurobiological disorders, autoimmune diseases, depression, and the treatment of chronic pain.

How does CBD work?

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All cannabinoids, including CBD, work by "attaching" to appropriate receptors to trigger a response. The human body currently has two primary types of receptors-CB1 and CB2. A third much less known receptor is TRPV1.

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The CB1 receptors first discovered in the brain, are also found in many other organs, in connective tissue and glands. The most important function of CB1 is the regulation of neurotransmitters in the brain. By activating the CB1 receptor, levels of substances such as serotonin and dopamine are stabilized. CBD connecting to the "other" side of the CB1 receptor initiates the so-called allosteric response - it does not directly cause a reaction in the body, but regulates the response of the receptor to other endocannabinoids connecting to its orthosteric side - the response is strengthened or weakened. .

Safety and side effects of CBD

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Recent studies conducted on both humans and animals have shown that CBD is a safe compound to use which also increases its therapeutic potential. CBD has also been studied in terms of side effects - no serious effects have been shown apart from occasional slowing down and nausea. Daily doses of up to 1500 mg were well tolerated by humans. CBD does not produce narcotic effects in humans or animals. CBD may interact with medications. CBD is metabolized by the cytochrome P450 enzyme system.  Therefore, it may increase or decrease blood concentrations of drug metabolites broken down in the liver.

Based on in vitro data, the effect of CBD-mediated inhibition of p-glycoprotein in the gut cannot be excluded. Therefore, caution is recommended during concomitant treatment with digoxin and other medicinal products that are substrates for p-glycoprotein. Caution should be exercised when using medicinal products with sleep-inducing, sedative, and potential sedative effects, due to possible additive effects on sedation and muscle tension reduction.

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